EPPP Physiology Practice Exam 2025 – Comprehensive Prep Tool

Benzodiazepines are known to cause addiction and withdrawal symptoms if stopped abruptly due to their mechanism of action and the way they affect the central nervous system. These medications are often prescribed for anxiety, insomnia, and other conditions. They work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased inhibition of neuronal activity. Over time, the body can develop a tolerance to benzodiazepines, requiring higher doses to achieve the same effect.

When a person who is dependent on benzodiazepines suddenly stops taking the medication, the brain, which has adapted to the presence of the drug, may experience a rebound effect. This can lead to symptoms such as heightened anxiety, seizures, tremors, and insomnia, which are indicative of withdrawal. It is essential for individuals who are taking benzodiazepines, especially for an extended period, to work with a healthcare professional for a gradual tapering of the dosage to minimize withdrawal symptoms.

While other substances listed, such as barbiturates and opioids, also have the potential for addiction and withdrawal, benzodiazepines are particularly noted for the significant challenges associated with abrupt discontinuation. Methylphenidate